The mulberry exhibits promising anti-inflammatory and anticancer properties

In laboratory and animal studies, maturation extracts showed potential as natural modulators of the immune system, activating defenses to combat inflammatory diseases. Mulberry alkaloids, such as 1-deoxynojirimycin (DNJ), also stimulate macrophages, key immune cells in the control of inflammation.

In addition, ripening leaf extracts, when treated under high pressure, have been shown to suppress the production of inflammatory molecules such as cytokines and nitric oxide. This effect further underlines the potential for maturation in reducing inflammation and related diseases.

Role of the mulberry bark in the fight against various cancers

The bark of mulberry, especially that of Morus alba (known as white mulberry or silkworm mulberry), appears to be a powerful ally in the fight against cancer. At the heart of this discovery is the morusine, a natural compound belonging to the flavonoid family. Flavonoids are known for their many health benefits, and the morusine is no exception.

Recent research, including a 2023 journal published in Frontiers in Molecular Biosciences, has shed light on the impressive anticancer properties of the morusine. This compound has been shown to be effective against various types of cancer, including those affecting the brain, breast, colon, liver, ovaries, pancreas and stomach.

One of the most fascinating aspects of the morusine is its ability to induce apoptosis, or programmed cell death, in cancer cell lines. This means that morusine can help remove cancer cells by triggering their self-destruction. Although the precise mechanisms behind the anticancer effects of the morusine are still under study, it is likely to interfere with crucial signalling pathways on which tumours depend for their growth and survival.

Breast cancer

Research into breast cancer cell lines has shown that morusine induces apoptosis in these cells. It works by influencing proteins that regulate cell death, for example by improving Bax levels, which promote apoptosis, and in particular survival levels, which help cancer cells escape death.

In simple terms, Bax acts as a switch that decides when a cell has to die. It promotes cell death when there is a problem, such as DNA damage or stress. In cancer, cells often prevent death, allowing them to grow in an uncontrolled manner. By increasing Bax levels in cancer cells, this could help cause their death, slowing down the growth of tumours.

Moreover, the morusine appears to trigger other forms of cell death, such as autophagy and necrosis.

Colorectal cancer

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