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Reported in a paper published in The New England Journal of Medicine, one patient saw an 18.5% decrease in their tumor size just two days after treatment. By day 69, the tumor had decreased by an incredible 60.7%. Another patient saw their ‘tumor regress rapidly’, according to the Mass General Brigham.
Following the third patient’s treatment, an MRI showed that a single infusion had led to a ‘near-complete tumor regression’ in just five days.
“The CAR-T platform has revolutionized how we think about treating patients with cancer, but solid tumors like glioblastoma have remained challenging to treat because not all cancer cells are exactly alike and cells within the tumor vary,” said Bryan Choi, MD, PhD, neurosurgeon and associate director of the Center for Brain Tumor Immunology and Immunotherapy, Cellular Immunotherapy Program, Mass General Cancer Center and Department of Neurosurgery.
He continued: “Our approach combines two forms of therapy, allowing us to treat glioblastoma in a broader, potentially more effective way.”
Mass General Brigham say studies similar to this one ‘show the promise of cell therapy for treating incurable conditions’, giving people considerable hope.
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