Prepless colon capsule technology: New research examines this less invasive approach to colorectal cancer screening

The same prepless capsule device underwent additional testing in a prospective multicenter trial conducted in Israel. During that trial, study participants underwent the capsule procedure and concomitant fecal immunochemical test (FIT) followed by colonoscopy, with removal of all visualized polyps.

Results from this trial were published in Gut in 2019 and included these relevant findings:

An analysis of 45 procedures performed demonstrated the sensitivity of both approaches for polyp detection: 44% using the capsule and 37% using FIT.
Capsule sensitivity increased to 78% to 100% when more than 50% to 70% of the colon surface area was imaged, respectively, with a linear correlation between imaged area and sensitivity. Specificity varied from 86% to 90%. Optimized scanning algorithms will be applied to future studies.

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